Selected research publications from Dr. Xin Tang and current/former lab members.

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25. Xin Y, Li K, Huang M, Liang C, Siemann D, Wu L, Tan Y, and Tang X, Biophysics in Tumor Growth and Progression: from Single Mechano-sensitive Molecules to Mechanomedicine. 2023, Oncogene (Springer Nature Publisher), https://doi.org/10.1038/s41388-023-02844-x.

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24. Huang M, Wang H, Mackey C, Chung M, Guan J, Zheng G, Roy A, Xie M, Vulpe, C, Tang X, YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer. International Journal of Molecular Science, 2023, 24(15), 12491; https://doi.org/10.3390/ijms241512491.

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23. Liang C, Huang M, Tanaka M, Lightsey S, Temples M, Lepler S, Sheng P, Mann W, Widener A, Siemann D, Sharma B, Xie M, Dai Y, Phelps E, Zeng B, Tang X,  Functional Interrogation of Ca2+ Signals in Human Cancer Cells In Vitro and Ex Vivo by Fluorescent Microscopy and Molecular Tools, In: Garcia-Cordero, J.L., Revzin, A. (eds) Microfluidic Systems for Cancer Diagnosis. Methods in Molecular Biology, 2023, vol 2679, doi:  https://doi.org/10.1007/978-1-0716-3271-0_7.

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22.  Liang C, Zheng Q, Chen X, Liu J, Tanaka M, Wang S, Lepler S, Jin Z, Siemann D, Zeng B, Tang X. Human Cancer Cells Generate Spontaneous Calcium Transients and Intercellular Waves That Modulate Tumor Growth. Biomaterials, 2022, (290), 121823, doi: 10.1016/j.biomaterials.2022.121823.

• The entire algorithm package is available upon request (xin.tang@ufl.edu) and in Github. 

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21. Liang C, Huang M, Li T, Li L, Sussman H, Dai Y, Siemann D, Xie M, Tang X. Towards An Integrative Understanding of Cancer Mechanobiology: Calcium, YAP, and MicroRNA Under Biophysical Forces. Soft Matter, 2022,18, 1112-1148.

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20. Luo Q, Zhang J, Lin G, Huang M, Tanaka M, Lepler S, Guan J, Siemann D, Tang X. Automatic Multi-functional Integration Program (AMFIP) Towards All-optical Mechanobiology Interrogation. PLOS One, 2022, 17(7): e0266098, doi:10.1101/2021.03.31.437936.

• The entire algorithm package is available upon request (xin.tang@ufl.edu) and in Github. 

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19. Huang M, Wang HY, Delgado AA, Reid TA, Long J, Wang S, Sussman H, Guan J, Yamaguchi H, Tang X, Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology, Journal of Visualized Experiments, 2022, (185), e64098, doi:10.3791/64098.

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18. Luo Q, Huang M, Liang C, Zhang J, Lin G, Yu S, Tanaka M, Lepler S, Guan J, Siemann D, Tang X. All-optical Mechanobiology Interrogation of Yes-asssociated Protein (YAP) in Human Cancer and Normal Cells Using A Novel Multi-functional System.  Journal of Visualized Experiments, 2021, (178), e62934, doi:10.3791/62934.

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17. Zhang Y, Shi X, Zhao T, Huang C, Wei Q, Tang X, Santy LC, Saif MTA, Zhang S. A traction force threshold signifies metastatic phenotypic change in multicellular epithelia. Soft Matter. 2019 Sep 18;15(36):7203-7210.

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16. Lee J, Abdeen AA, Tang X, Saif TA, Kilian KA. Matrix Directed Adipogenesis and Neurogenesis of Mesenchymal Stem Cells Derived from Adipose Tissue and Bone Marrow. Acta Biomaterlia, 2016, 42:46-55. doi: 10.1016/j.actbio.2016.06.037.

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15. Lee J, Abdeen AA, Tang X, Saif TA, Kilian KA. Geometric Guidance of Integrin Mediated Traction Stress During Stem Cell Differentiation. Biomaterials, 2015, 69:174-83.doi: 10.1016/j.biomaterials.2015.08.005

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14. Tang X, Kuhlenschmidt TB, Li Q, Ali S, Lezmi S, Chen H, Pires-Alves M, Laegreid WW, Saif TA, Kuhlenschmidt MS. A Mechanically-induced Colon Cancer Cell Population Shows Increased Metastatic Potential. Molecular Cancer, 2014, 13:131. doi: 10.1186/1476-4598-13-131.

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13. Tang X, Tofangchi A, Anand SV, Saif TA. A Novel Cell Traction Force Microscopy to Study Multi-cellular System. PLoS Computational Biology, 2014,10(6):e1003631, doi: 10.1371/journal.pcbi.1003631.

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12. Tang X, Saif T. Adhesivity of Colon Cancer Cells during in vitro Metastasis. International journal of applied mechanics. 2013; 05(03).

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11. Tang X, Wen Q, Kuhlenschmidt TB, Kuhlenschmidt MS, Janmey PA, Saif TA. Attenuation of cell mechanosensitivity in colon cancer cells during in vitro metastasis. PLoS One. 2012;7(11): e50443.

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10. Tang X, Ali MY, Saif MT. A Novel Technique for Micropatterning Proteins and Cells on Polyacrylamide Gels. Soft Matter. 2012 Jul 21;8(27):7197-7206.

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9. Cha C, Jeong JH, Tang X, Zill AT, Prakash YS, Zimmerman SC, Saif TA, Kong H. Top-down synthesis of versatile polyaspartamide linkers for single-step protein conjugation to materials. Bioconjug Chem. 2011 Dec 21;22(12):2377-82.

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8. Tang X, Li D, Lewandowski J, Prakash V. Effects of Microstructure on High Strain Rate Deformation and Flow Behavior of Al–Mg–Si Alloy (AA 6061) under Uniaxial Compression and Combined Compression and Shear Loading. Materials Science and Technology. 2011; 27(1):13.

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7. Tang X, Bajaj P, Bashir R, Saif T. How Far Cardiac Cells Can See Each Other Mechanically. Soft matter (Cover Article). 2011; 7:6151.

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6. Bajaj P, Tang X, Saif TA, Bashir R. Stiffness of the substrate influences the phenotype of embryonic chicken cardiac myocytes. J Biomed Mater Res A. 2010 Dec 15;95(4):1261-9.

 

5. Tang X, Kuhlenschmidt TB, Zhou J, Bell P, Wang F, Kuhlenschmidt MS, Saif TA. Mechanical force affects expression of an in vitro metastasis-like phenotype in HCT-8 cells. Biophysical Journal (Cover Article). 2010 Oct 20;99(8):2460-9.

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4. Tang X, Prakash V, Lewandowski J. Dynamic Tensile Deformation of Aluminum Alloy 6061-T6 and 6061-OA. Journal of Experimental Mechanics. 2007; 22(3):305.

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3. Tang X, Lewandowski J, Prakash V, Kooistra G, Wadley H. Inertial Stabilization of Buckling at High Rates of Loading and Low Test Temperatures: Implications for Dynamic Crush Resistance of Aluminum-alloy-based Sandwich Plates with Lattice Core. Acta Materialia. 2007; 55(8):2829.

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2. Wang R, Tang X, Wang D, He S. Measurement of Variedline-space Grating Line Frequency by Phase-shift Moiré Interferometry. Journal of University of Science and Technology of China. 2004; 34(5).

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1. Wang R, Tang X, Cao Y, He S. Measurement of Two dimensional Varied-linespace Gratings. Journal of Experimental Mechanics. 2004; 19(3):324.